Jika dikonsumsi bersama sildenafil, bosentan dapat menurunkan kadar konsentrasi plasma sildenafil pada tubuh secara signifikan sehingga pengobatan berjalan kurang efektif.  Jika tidak digunakan dalam dosis yang tepat atau memiliki kondisi medis tertentu, sildenafil dapat memicu beberapa efek samping umum seperti: Sementara untuk pengobatan h

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